Haemolytic disease of the newborn; criteria of severity.

Examination of Liquor Amnii as a Method of Predicting Severity of Haemolytic Disease of Newborn.

A case for comprehensive antenatal screening for blood group antibodies.

OBJECTIVES To determine the frequency of various blood group antibodies responsible for haemolytic disease of the new born (HDN). DESIGN A prospective study of all neonates and still born foetuses suspected to have haemolytic disease of the new born and their mothers. SUBJECTS Neonates suspected to have HDN as per study criteria along with their mothers and mothers of still born foetuses wi...

Decrease of serum cholesterol ester in haemolytic disease of the newborn.

The conception of the pathological entity of the three manifestations of haemolytic disease of the newborn: hydrops foetalis, icterus gravis and congenital haemolytic anaemia has been confirmed by the discovery of the Rhesus factor. Moreover, this discovery has allowed us finally to abandon any sharp clinical distinction between the two latter forms of the disease. This is in accord with the fa...

A case of severe haemolytic disease of the newborn due to anti-Di(a) antibody.

Red cell allo-antibodies directed against the Diego (Di) blood group antigen have rarely been reported to cause a haemolytic reaction against transfusion or haemolytic disease of the newborn. The frequency of the Di(a+) phenotype among the Hong Kong Chinese population is estimated to be 4.4%. We report on a case of severe haemolytic disease of the newborn due to anti-Di(a) antibody--the first l...

ABO Hemolytic Disease Leading to Hyperbilirubinemia in Term Newborns: Value of Immunohematological Tests

Introduction ABO hemolytic disease of the newborn is most common cause of neonatal jaundice; previous studies have shown a poor correlation between serologic tests and clinical course in affected infants. The aim of this study was to identify the value of direct and indirect Coombs’ immunohematological tests, to identify the incidence of hemolytic disease in newborns (ABO-HDN). Methods : This  ...

Haemolytic Disease of the Newborn*

Since the discovery of the Rh blood groups (Landsteiner and Weiner, 1940) many articles on the subject of haemolytic disease of the newborn have been written. Gilmour (1944) in this country and Potter (1944; 1946) in America have presented authoritative accounts of the pathology of haemolytic disease, but, as the former points out, this aspect of the condition has received far less attention th...